[Cusom28] Ciliary Dysfunction_Follow-up on topic in A13-Epithelium Histology

[Brenseke, Bonnie]

Dear Class of 2028,

As discussion was had this morning about ciliary dysfunction/ciliary dyskinesia, below is a StatPearls article on the topic with pertinent excerpts pulled and bulleted.
[Cover of StatPearls]Ciliary Dysfunction
https://www.ncbi.nlm.nih.gov/books/NBK448201/

*         Different mutations, even to the same gene, can result in varying degrees of loss of function of the cilia, further contributing to the heterogeneity of the disease.

*         The sperm tail and fimbriae of fallopian tubes also have motile cilia. Therefore, male and female infertility often occurs. Situs abnormalities occur in about 50% of cases of PCD. Normal ciliary movement is needed for visceral rotation. In the absence of normal ciliary function during embryogenesis, abnormal orientation can result. Kartagener syndrome is a triad of chronic sinusitis, bronchiectasis, and situs inversus resulting from ciliary dysfunction.

All the best,

Bonnie Brenseke, DVM, PhD, DACVP
Associate Professor and Biomedical Chair of Pathology
School of Osteopathic Medicine | Campbell University
Levine Hall Office #165 | (910) 893-1746
[cid:image001.png at 01D2F654.FC2B2F20]<http://medicine.campbell.edu/>

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