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<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Bahnschrift Light SemiCondensed",sans-serif">Dear Class of 2028,
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Bahnschrift Light SemiCondensed",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Bahnschrift Light SemiCondensed",sans-serif">As discussion was had this morning about ciliary dysfunction/ciliary dyskinesia, below is a StatPearls article on the topic with pertinent excerpts
pulled and bulleted. <o:p></o:p></span></p>
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<img width="59" height="74" style="width:.6145in;height:.7708in" id="Picture_x0020_2" src="cid:image005.jpg@01DB04F9.74BC8000" alt="Cover of StatPearls"><b><span style="font-size:18.5pt;font-family:"Arial",sans-serif;color:black">Ciliary Dysfunction<o:p></o:p></span></b></p>
<p class="MsoNormal"><a href="https://www.ncbi.nlm.nih.gov/books/NBK448201/">https://www.ncbi.nlm.nih.gov/books/NBK448201/</a><o:p></o:p></p>
<p class="MsoListParagraph" style="text-indent:-.25in;mso-list:l0 level1 lfo1"><![if !supportLists]><span style="font-family:Symbol"><span style="mso-list:Ignore">·<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]>Different mutations, even to the same gene, can result in varying degrees of loss of function of the cilia, further contributing to the heterogeneity of the disease.<o:p></o:p></p>
<p class="MsoListParagraph" style="text-indent:-.25in;mso-list:l0 level1 lfo1"><![if !supportLists]><span style="font-family:Symbol"><span style="mso-list:Ignore">·<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]>The sperm tail and fimbriae of fallopian tubes also have motile cilia. Therefore, male and female infertility often occurs. Situs abnormalities occur in about 50% of cases of PCD. Normal ciliary movement is needed for visceral
rotation. In the absence of normal ciliary function during embryogenesis, abnormal orientation can result. Kartagener syndrome is a triad of chronic sinusitis, bronchiectasis, and situs inversus resulting from ciliary dysfunction.<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Bahnschrift Light SemiCondensed",sans-serif">All the best,</span><o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><span style="font-size:11.5pt;font-family:"Arial Narrow",sans-serif;color:#404040">Bonnie Brenseke, DVM, PhD, DACVP<br>
Associate Professor and Biomedical Chair of Pathology <o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.5pt;font-family:"Arial Narrow",sans-serif;color:#404040">School of Osteopathic Medicine | Campbell University<br>
Levine Hall Office #165 | (910) 893-1746<o:p></o:p></span></p>
<p class="MsoNormal"><a href="http://medicine.campbell.edu/"><span style="color:windowtext;text-decoration:none"><img border="0" width="309" height="38" style="width:3.2187in;height:.3958in" id="Picture_x0020_1" src="cid:image006.png@01DB04F9.74BC8000" alt="cid:image001.png@01D2F654.FC2B2F20"></span></a><o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
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